The Whyte Group of Companies

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Our primary product manufactured at Grosvenor Chemicals Ltd. is N,N Diisopropylethylamine (Huenigs Base / DIEA), as well as being an intermediate used in Pharmaceutical synthesis, it is also widely used as a proton scavenger in Peptide coupling.

Therefore we also offer a wide range of Peptide Synthesis reagents including Coupling reagents, FMoc, Boc and CBZ protecting group reagents, and various protected amino acids.

A presentation on Peptide Synthesis reagents from
Whyte Chemicals Ltd. can be accessed via the link below.

Click for Peptide Presentation

Coupling Reagents:

TBTU (o-Benzotriazol-1-yl-N,N,N',N'-tetramethyluronium tetrafluoroborate)
HBTU (o-Benzotriazol-1-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate)
HOBt anhydrous (1 Hydroxybenzotriazole anhydrous)

HOBT monohydrate (1 Hydroxybenzotriazole monohydrate)
HOSu (N Hydroxy Succinimide)
DIC (1,3 Diisopropyl Carbodiimide)

CDI (Carbonyl Diimidazole)

New products include the following ‘next generation’ coupling reagents, which have superior coupling efficiencies, and are less hazardous compounds than their counterparts TBTU, HBTU and HOBT

TCTU(1H-Benzotriazolium,1-[bis(dimethylamino)methylene]-5-chloro-tetrafluoroborate 

(1-),3 oxide

HCTU(1H-Benzotriazolium,1-[bis(dimethylamino)methylene]-5-chloro-hexafluorophosphate

(1-),3 oxide

6-Cl-HOBT (6-Chloro-1-Hydroxy-1H-Benzotriazole)

 Comparative technical data is available on request.

Reagents for protected amino acid synthesis:

Fmoc OSu (9-Fluoromethyl succinimidyl carbonate)
Z-Osu (N-[Benzyloxycarbonyloxy]succinimide)

2-Chloro-Z-Osu (2-Chlorobenzyloxy carbonyloxy succinimide)
2-Bromo-Z-Osu (2-Bromobenzyloxy carbonyloxy succinimide)
DiBoc (Di-tert-butyl dicarbonate)

Protected Amino Acids:

We currently offer the following protected amino acids as well as their CBZ and Boc derivatives, please feel free to contact us with inquiries for any protected amino acid not listed below.

Fmoc-L-Alanine-OH

Fmoc-D-Alanine-OH

Fmoc-Arginine(PbF)-OH

Fmoc-Asparagine-OH

Fmoc-Asparagine(Trt)-OH

Fmoc-Aspartic acid (Obut)-OH

Fmoc-Cysteine(Trt)-OH

Fmoc-Glutamine-OH

Fmoc-Glutamic acid (OtBu)-OH

Fmoc-Glycine-OH

Fmoc-Histidine-(Mtt)-OH

Fmoc-Histidine-(trt)-OH

Fmoc-Isoleucine-OH

Fmoc-Leucine-OH

Fmoc-Lysine-OH

Fmoc-Lysine-(Boc)-OH

Fmoc-Methionine-OH

Fmoc-Phenylalanine-OH

Fmoc-Proline-OH

Fmoc-Serine-OH

Fmoc-Serine(tBu)-OH

Fmoc-Threonine-OH

Fmoc-Threonine(tBu)-OH

Fmoc-Tryptophan-OH

Fmoc-Tryptophan(Boc)-OH

Fmoc-Tyrosine-OH

Fmoc-Tyrosine-(tBu)-OH

Fmoc-Valine-OH

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Last modified: March 18, 2002